One Health is a collaborative, multi-sector, transdisciplinary approach to achieving optimal health outcomes among people, animals, plants, and their shared environment. Scientists working with a One Health focus have seen increased antimicrobial-resistant bacteria in the environment. Antimicrobial-resistant bacteria in the environment occur naturally but can also be impacted by humans’ antibiotic use and disposal decisions. This antimicrobial resistance can impact humans if they swim with a cut in a waterway that contains resistant bacteria.